Case Report

Acquired hemophilia in a patient with systemic lupus erythematosus: a case report and literature review

Authors

Mitsuteru Akahoshi^1,4, Kumiko Aizawa¹, Shuji Nagano¹, Hisako Inoue^1,2, Atsushi Sadanaga¹, Yojiro Arinobu¹, Hiroaki Niiro¹ and Hitoshi Nakashima^1,3

1. Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
2. Department of Internal Medicine, Saga University School of Medicine, Saga 849-8501, Japan
3. Division of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan
4. Present address: Department of Internal Medicine, Chihaya Hospital, 2-30-1 Chihaya, Higashi-ku, Fukuoka 813-8501, Japan

Received:

12 February 2008

Accepted:

15 April 2008

Published online:

13 June 2008

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Abstract

We report the case of a 38-year-old female patient with systemic lupus erythematosus (SLE) who developed acquired hemophilia caused by factor VIII (FVIII) inhibitors. She manifested spontaneous bleeding symptoms such as ecchymoses and hematuria. Laboratory findings showed an isolated prolongation of the activated partial thromboplastin time, reduced FVIII activity, and a high titer of FVIII inhibitors. She was successfully treated with oral predonisolone and cyclosporine in combination with steroid and cyclophosphamide pulse therapy.

Key words

Acquired hemophilia - Factor VIII inhibitor - Systemic lupus erythematosus - Bleeding