Case Report

Successful treatment with plasma exchange in adult-onset Still’s disease with hyper-IL-18-naemia and hyperallergic state

Authors

Tomoki Ito¹, Yoshio Ozaki¹, Keiko Shimamoto¹, Hideki Amuro¹, Tsutomu Tanijiri¹, Takashi Yokoi¹, Yonsu Son¹, Kenichirou Tajima¹ and Shirou Fukuhara¹

1. First Department of Internal Medicine, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi Osaka, 570-8506, Japan

Received:

5 September 2007

Accepted:

3 March 2008

Published online:

29 April 2008

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Abstract

Adult-onset Still’s disease (AOSD) is a rheumatoid disorder characterized by high fever, polyarthritis, leukocytosis, hyperferritinaemia, and mild liver involvement. We describe the case of a patient with AOSD with severe liver dysfunction. His serum levels of interleukin-10 and 18 showed a similar trend to his disease activity. Drug lymphocyte stimulation tests were positive for three drugs in the patient. Hypercytokinaemia was controlled by plasma exchange therapy.

Key words

Adult-onset Still’s disease - Drug lymphocyte stimulation test - Hepatitis - Interleukin-10