ORIGINAL ARTICLE
Anticyclic citrullinated peptide antibodies in juvenile idiopathic arthritis
Authors
Jürgen K.H. Brunner1 and Friedrich C. Sitzmann2
| (1) |
Department of Pediatrics, Innsbruck Medical School, Anichstrasse 35, A-6020 Innsbruck, Austria |
| (2) |
Department of Pediatrics, University of Saarland, 66421 Homburg/Saar, Germany |
Full Text（PDF)
Received: April 19, 2006 Accepted: August 31, 2006
Abstract
Anticyclic citrullinated peptide (anti-CCP) antibodies
have been detected in patients with juvenile idiopathic
arthritis (JRA), particularly in those with
polyarticular JIA. We analyzed the presence of anti-CCP
antibodies of the IgG class in sera of patients with defined
juvenile idiopathic arthritis (JIA) of various subgroups.
One hundred and fifty-nine serum samples were investigated.
Forty-five patients were diagnosed with JIA (15 male
and 30 female) aged 1.9・7.3 years (median 12.9, mean
11.0). Thirty-eight samples were taken from patients suffering
from other autoimmunopathies and 34 patients with
other underlying diseases were taken at different time
points in their disease course. Under 42 samples were taken
from patients with noninflammatory diseases. Enzymelinked
immunosorbent assay (ELISA) was used for the detection
of anti-CCP antibodies. Anti-CCP antibodies were
found in 6.9% of all samples and in 4.4% patients with JIA.
Disease duration and medication did not differ significantly
between anti-CCP positive and negative patients. A review
of the literature and our own results shows that anti-CCP
antibodies can be detected in the sera of only some patients
with JIA. Routine determination of anti-CCP cannot be
recommended.
Key words
Anticyclic citrullinated peptide (anti-CCP), Juvenile idiopathic arthritis
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