CASE REPORT
A pediatric patient with neuro-Behcet's disease
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Saori Hatachi1,2, Takashi Nakazawa1, Akio Morinobu1, Shinpei Kasagi1, Yoshinori Kogata1, Gohichi Kageyama1,3, Seiji Kawano1, Masahiro Koshiba1,4 and Shunichi Kumagai1
| (1) |
Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan |
| (2) |
Present address: Department of Medicine, Division of Clinical Immunology and Rheumatology, Kitano Hospital, Osaka, Japan |
| (3) |
Present address: Division of Rheumatology, Kurashiki Central Hospital, Kurashiki, Japan |
| (4) |
Present address: Department of Clinical Laboratory Medicine, Hyogo College of Medicine, Nishinomiya, Japan |
Received: 10 March 2006 Accepted: 22 June 2006
Abstract Behcet's disease is rare in childhood. We describe a 10-year-old boy with neuro-Behcet's disease (NB) who presented with fever, headache, vertigo, and hearing loss. An examination of the cerebrospinal fluid (CSF) revealed pleocytosis as well as elevated protein and interleukin (IL)-6 levels. Brain magnetic resonance imaging (MRI) showed hyperintensity of the right thalamus and midbrain on T2-WI, and gadolinium (Gd) enhancement of left acoustic nerve origin. HLA-B51 was positive. Prednisolone combined with methotrexate resulted in a complete remission. Brain MRI and the CSF IL-6 level were useful for the diagnosis and monitoring of this pediatric patient with NB.
Key words Cerebrospinal fluid (CSF) - Child - Interleukin (IL)-6 - Magnetic resonance imaging (MRI) - Neuro-Behcet's disease (NB)
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