CASE REPORT
Tacrolimus treatment for refractory lupus cystitis
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Satoshi Oda1, Hiroshi Fujinaga1 and Kozo Takahashi1
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Department of Medicine, Division of Respiratology and Neurology, Kurume University School of Medicine, 67 Asahimachi, Kurume 830-0011, Japan |
Received: 28 November 2005 Accepted: 19 May 2006
Abstract A 23-year-old woman presented with recurrence of lupus cystitis, which had been in remission under daily administration of a single corticosteroid over a period of 8 years. She was treated with increased doses of corticosteroid and immunosuppressants, i.e., cyclosporin, cyclophosphamide, azathioprine, and salazosulfapyridine, but the cystitis remained active. Since her condition became critical by the complication of intestinal pseudo-obstruction, tacrolimus was administered. This agent induced a remission promptly without significant adverse events in this patient, suggesting an efficacy to lupus cystitis refractory to corticosteroid and other immunosuppressants.
Key words Corticosteroid - Cyclosporin - Lupus cystitis - Refractory - Tacrolimus
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