CASE REPORT
Drug eruption due to bosentan in a patient with systemic sclerosis
Yayoi Nagai1, Masayoshi Yamanaka1, Shigeru Nishimura2, Akihiko Nakano2, Akira Hasegawa2 and Osamu Ishikawa1
| (1) |
Department of Dermatology, Gunma University Graduate School of Medicine, 3-39-22 Showamachi, Maebashi 371-8511, Japan |
| (2) |
Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan |
Received: 21 February 2006 Accepted: 28 March 2006
Abstract We present the case of a 60-year-old female patient with systemic sclerosis complicated by pulmonary hypertension. Ten days after the initiation of treatment with bosentan, high fever and skin eruptions were noted. In the previous reports, the frequency of drug-induced skin eruptions has not been well documented. Since the use of bosentan is expected to increase, we should be aware of the previously unknown adverse effects as well as skin eruptions.
Key words Bosentan - Drug eruption - Endothelin-receptor antagonist - Pulmonary arterial hypertension (PAH) - Systemic sclerosis (SSc) |
