CASE REPORT
A case of Epstein Barr virus-associated natural killer/T-cell lymphoma presenting as dermatomyositis: extranodal relapse after 7 years in remission
Yoshiko Hashimoto1 , Naoko Hashimoto1, Shunsuke Furuta1, Takeaki Sugawara2, Nobuharu Kosugi2, Maki Hata3 and Masanobu Eguchi4
(1)
|
Department of Rheumatology, Numazu City Hospital, 550 Harunoki, Aza, Higashi-shiiji, Numazu 410-0302, Japan |
| (2) |
Department of Hematology, Numazu City Hospital, Numazu, Japan |
| (3) |
Department of Dermatology, Numazu City Hospital, Numazu, Japan |
| (4) |
Department of Pathology, Numazu City Hospital, Numazu, Japan |
Received: 29 July 2005 Accepted: 13 September 2005
Abstract A 56-year-old Japanese man was admitted to our hospital due to a fever of unknown origin. He had had a history of extranodal natural killer (NK)/T-cell lymphoma, nasal type, and had been in complete remission for 7 years until June 2003, when he developed high fever, eyelid swelling, and muscular weakness. Serum creatine kinase levels were elevated. Histopathological examination of skin and muscle biopsy specimens revealed subcutaneous infiltration of lymphoid cells positive for CD3, CD56, and Epstein Barr virus-encoded small nuclear RNA-1. We report this unique case of Epstein Barr virus-associated lymphoma mimicking dermatomyositis.
Key words Dermatomyositis - Epstein Barr virus (EBV) - Natural killer (NK)/T-cell lymphoma
