CASE
REPORT
Bronchiolar disease associated
with gold compounds administration in a patient with
rheumatoid arthritis
Kazuko Hiramatsu1, 2 ,
Hiroshi Ishizuka1 and Miyako Yamasaki1
Full
Text (PDF)
| (1) |
Department of Internal
Medicine, Kawasaki Kyodo Hospital, 2-1-5 Sakuramoto,
Kawasaki-ku, Kawasaki 210-0833, Japan |
| (2) |
Present address:
Department for Rheumatic Diseases, Tokyo Metropolitan
Fuchu General Hospital, 2-9-2 Musashidai, Fuchu
183-8524, Japan |
Received: 09 August
2004 Accepted: 13 January 2005
Abstract We report the case of a
female patient with rheumatoid arthritis (RA) treated
with gold sodium thiomalate and auranofin who developed
bronchopulmonary involvement. Chest X-ray films showed
diffuse mottled infiltrates and bronchial wall thickness
in both lungs. Computed tomography revealed opacities
along the thickening of the bronchovascular bundles.
The pathologic findings were indistinguishable from
those of diffuse panbronchiolitis. After discontinuation
of gold compounds and initiation of steroid administration,
her subjective symptoms immediately subsided. We conclude
that our patient, who had suffered from chronic sinusitis
and had a predisposition to bronchiolar disease, had
bronchiolar disease induced by gold compounds.
Key
words Bronchiolar disease - Diffuse
panbronchiolitis - Disease-modifying antirheumatic drugs
(DMARDs) - DMARDs-induced pulmonary injury - Gold compounds
- Rheumatoid arthritis (RA)
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