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MR Vol.14 No.6 indexに戻る
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MODERN RHEUMATOLOGY Vol.14 No.6 |
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Revised Japanese criteria for Sjogren's syndrome (1999): availability and validity |
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| Takashi Fujibayashi1, Susumu Sugai2, Nobuyuki Miyasaka3, Yoshio Hayashi4 and Kazuo Tsubota5 |
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Department of Oral and Maxillofacial Surgery, Showa University School of Dentistry, 2-1-1 Kitasenzoku, Ohta-ku, Tokyo 145-8515, Japan |
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Department of Hematology and Immunology, Kanazawa Medical University, Kanazawa, Japan |
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Department of Bioregulatory Medicine and Rheumatology, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo, Japan |
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Department of Pathology, School of Dentistry, University of Tokushima, Tokushima, Japan |
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Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan |
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4-17-810 Minamimotomachi, Shinjuku-ku, Tokyo 160-0012, Japan |
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| Abstract |
| The Japanese criteria for diagnosing Sjogren's syndrome (SS) were revised in 1999, and consist of four major areas: histopathology, oral examination, ocular examination, and serological examination. A diagnosis of SS can be made when the patient meets at least two of these four criteria. This report describes how the revised Japanese criteria were established. After the publication of the revised Japanese criteria (1999), a research study which focused on evaluating its availability and validity was carried out in 2001 using funds from Grant-in-Aids for Scientific Research supported by the Japan Society for the Promotion of Science. The availability of the revised criteria was investigated by a questionnaire study through the Japanese Medical Society for Sjogren's Syndrome, and the use of the revised criteria for diagnosing SS in these medical facilities was found to be 76%. To evaluate the validity of the revised criteria, the records of 900 patients, including SS patients and non-SS controls, from 54 clinical centers were registered and analyzed to calculate the accuracy of the criteria. The revised Japanese criteria were found to have 96.0% sensitivity, 90.5% specificity, and 94.5% accuracy for diagnosing SS. |
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| Key words |
| Diagnostic criteria - Revised Japanese criteria - Sensitivity - Sjogren's syndrome (SS) - Specificity |
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