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MR Vol.14 No.4 indexに戻る
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MODERN RHEUMATOLOGY
Vol.14 No.4 |
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A case of acquired hemophilia caused by factor VIII inhibitor with rheumatoid arthritis, successfully treated with immunosuppressive treatment and recombinant activated factor VII |
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| Takeo Sato1 , Kiyofumi Hagiwara1, Junnichi Chikazoe1, Yasunori Nakagawa2 and Osamu Akiyama1 |
(1) Department of Allergy and Rheumatology, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo, 150-8935, Japan
(2) Department of Hematology, Japanese Red Cross Medical Center, Tokyo, Japan
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Received: 04 September 2003 Accepted: 05 March 2004 |
| Abstract |
| We report the case of a patient who presented with acquired hemophilia associated with rheumatoid arthritis. The patient's factor VIII activity was less than 1% and factor VIII inhibitor was detected. Based on the blood analysis, the patient was diagnosed as having the factor VIII inhibitor. She was successfully treated with prednisolone, cyclophosphamide, and gammaglobulin to suppress the factor VIII inhibitor, and the administration of recombinant activated factor VII was effective in controlling severe bleeding episodes |
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| Key words |
| Acquired hemophilia - Factor VIII - Intramuscular hemorrhage - Recombinant activated factor VII (rFVIIa) - Rheumatoid arthritis (RA) |
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