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MR Vol.14 No.3 indexに戻る
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MODERN RHEUMATOLOGY
Vol.14 No.3 |
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Human leukocyte antigen haplotype and autoantibodies
of a family with systemic lupus erythematosus |
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| Yoshio Ozaki1 , Yonsu Son1, Kengo Nakamura1,
Masashi Takebayashi1, Minori Nagahama1, Hideo Kagawa1 and Shirou
Fukuhara1 |
| (1) First Department of Internal Medicine, Kansai
Medical University, 10-15 Fumizono-cho, Moriguchi, 570-8506, Japan |
Received: 26 May 2003 Accepted:
04 March 2004 |
| Abstract |
| A search for HLA haplotypes of a family of
five indicated that four members had the same haplotype. Systemic
lupus
erythematosus (SLE) had already developed in three of these four
people. SLE has now developed in the remaining person, and the result
is that all the members of the family having the same haplotype will
develop SLE. Regarding these four SLE patients, the types of autoantibodies
and the symptoms were different in each person, so the idea that
this haplotype is strongly related to the onset of SLE but minimally
related to the symptoms was suggested. |
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| Key words |
| Autoantibody - Family study - Human leukocyte
antigen (HLA)-haplotype - Susceptibility - Systemic lupus erythematosus
(SLE) |
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