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MR Vol.14 No.3 indexに戻る
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MODERN RHEUMATOLOGY
Vol.14 No.3 |
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A case of mixed connective tissue disease presenting
with nephrotic syndrome |
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| Hiro Kuroda1 , Keita Ishii1, Yuji Negoro1, Hiroko
Sugiyama1, Junko Inoue1, Chiga Ogurusu1, Takeshi Kikuchi1, Keisei
Shimoe2 and Katsutoshi Sunami3 |
(1) Department of Internal Medicine, Chugoku
Central Hospital of the Mutual Aid Association of Public School Teachers,
6-3-1 Nishifukatsu-cho, Fukuyama, 721-8581, Japan
(2) Department of Dermatology, Chugoku Central Hospital of the Mutual Aid Association
of Public School Teachers, Fukuyama, Japan
(3) Department of Orthopedic Surgery, Chugoku Central Hospital of the Mutual
Aid Association of Public School Teachers, Fukuyama, Japan |
Received: 23 April 2003 Accepted:
03 February 2004 |
| Abstract |
| A 70-year-old woman was admitted to our hospital
for the treatment of diffuse scleroderma and marked edema in the
lower extremities. Renal biopsy revealed membranous change, interstitial
nephritis, and intimal hyperplasia of the small arteries. The patient
was diagnosed as having mixed connective tissue disease (MCTD) presenting
with nephrotic syndrome (NS). She responded well to a combination
treatment consisting of methylprednisolone (m-PSL) pulse therapy,
oral PSL, and cyclosporine A (CsA). We speculated on the actual pathogenesis
of NS in this case of MCTD. |
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| Key words |
| Corticosterioid - Cyclosporine A (CsA) - Mixed
connective tissue disease (MCTD) - Nephrotic syndrome (NS) |
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