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MR Vol.14 No.2 indexに戻る
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MODERN RHEUMATOLOGY
Vol.14 No.2 |
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Thrombotic thrombocytopenic purpura complicating
SjOgrens syndrome with crescentic glomerulonephritis and membranous
nephritis
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| Haruo Abe1 , Norioki Tsuboi1, Sonosuke Yukawa1,
Souichirou Tsuji1, Haeru Hayashi1, Naoichiro Yukawa1, Hirofumi Takanashi1,
Koichiro Tahara1, Norihiko Tonozuka1 and Tohru Hayashi1 |
| (1) Third Department of Internal Medicine,
Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo,
160-0023, Japan |
Received: 26 March 2003 Accepted: 12 December
2003 |
| Abstract |
| The association of either thrombotic thrombocytopenic
purpura (TTP) or crescentic glomerulonephritis with SjOgrens syndrome
is rare. We report a case of TTP appearing after the diagnosis of
SjOgrens syndrome with crescentic glomerulonephritis and membranous
nephropathy. Circulating immune complex was detected, and immune
complex deposits were shown along the capillary walls of renal biopsy
specimens. Despite steroid pulse therapy and plasma exchange therapy,
the patient died. The etiology of TTP is unclear. This case is important
when considering the etiology of TTP related to autoimmune disease. |
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| Key words |
| Crescentic glomerulonephritis - Immune complex (IC)
- Membranous nephropathy (MN) - SjOgrens syndrome (SS) - Thrombotic
thrombocytopenic purpura (TTP) |
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