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MR Vol.14 No.2 indexに戻る
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MODERN RHEUMATOLOGY
Vol.14 No.2 |
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Marked hypocomplementemia and tubulointerstitial
nephritis in a male patient with SjOgrens syndrome
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| Naoichiro Yukawa1 , Norioki Tsuboi1, Sonosuke
Yukawa1, Haeru Hayashi1, Taisuke Arai1, Haruo Abe1, Koichiro Tahara1,
Hirofumi Takanashi1 and Tohru Hayashi1 |
| (1) Third Department of Internal Medicine,
Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo,
160-0023, Japan |
Received: 22 November 2002 Accepted: 22 August
2003 |
| Abstract |
| We report a case of marked hypocomplementemia
and tubulointerstitial nephritis associated with SjOgrens syndrome
(SS) in a male patient. Renal biopsy revealed tubulointerstitial
nephritis but did not identify specific immune deposits of the tubulointerstitium.
After steroid therapy, the renal failure and hypocomplementemia diminished.
Hypocomplementemia without cryoglobulinemia is not commonly observed
in SS patients, and hypocomplementemic tubulointerstitial nephritis
was strongly suspected. Hypocomplementemic tubulointerstitial nephritis
is rare; only one case has been described in the literature. In our
case and the previous case, the patients were elderly men, and they
had some similar clinical characteristics. Idiopathic hypocomplementemic
tubulointerstitial nephritis resembling our case has been reported.
These facts suggest that hypocomplementemic tubulointerstitial nephritis
may occur in patients with SS, and such cases may not be as rare
as once thought because it might be appropriate to include them in
the category of idiopathic cases. Such a syndrome should be included
in the differential diagnosis of hypocomplementemia. |
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| Key words |
| Hypergammaglobulinemia - Hypocomplementemia
- Male - SjOgrens syndrome (SS) - Tubulointerstitial nephritis (TIN) |
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