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MR Vol.14 No.2 indexに戻る
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MODERN RHEUMATOLOGY
Vol.14 No.2 |
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Tartrate-resistant acid phosphatase-positive
cells in the synovial?cartilage junction and bone marrow during the
progression of collagen-induced arthritis in adult rats |
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| Hiroyuki Mizumura1 , Shinji Nishihara1, Yuji
Kishimoto1, Yasuo Morio1 and Ryota Teshima1 |
| (1) Department of Orthopedic Surgery, Faculty
of Medicine, Tottori University, 36-1 Nishi-cho, Yonago, 683-8504,
Japan |
Received: 19 May 2003 Accepted: 09 October 2003 |
| Abstract |
| We investigated the time-course changes in
bone destruction in rats with collagen-induced arthritis (CIA). The
synovial?cartilage
junction (SCJ) and epiphyseal bone marrow of the femoral posteromedial
condyle in CIA rats were evaluated histologically and immunohistologically
at 2, 3, 4, 6, and 8 weeks after sensitization. Two weeks after sensitization,
tartrate-resistant acid phosphatase (TRAP)-positive multinuclear
cells formed resorption lacunae on the lateral side of the cortical
bone under the SCJ. No resorption lacunae were observed in bone marrow.
Three weeks after sensitization, resorption lacunae on the lateral
side of the cortical bone expanded, but no bone marrow invasion by
pannus was observed. In bone marrow, many TRAP-positive multinuclear
cells appeared and formed resorption lacunae in subchondral bone.
Four weeks after sensitization, cortical bone was destroyed, and
pannus had invaded the bone marrow. After six weeks, trabecular bone
and subchondral bone plate were extensively resorbed by TRAP-positive
cells. Bone destruction in CIA began with the appearance of TRAP-positive
cells on the lateral side of the cortical bone under the SCJ, followed
by the TRAP-positive multinuclear cells in bone marrow, which were
morphologically unconnected to the SCJ lesions. These histological
findings suggested that bone destruction in the early stage of arthritis
occurred in two anatomically different regions. |
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| Key words |
| Bone destruction - Collagen-induced arthritis
(CIA) - Osteoclast - Tartrate-resistant acid phosphatase (TRAP) |
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