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MR Vol.14 No.2 indexに戻る
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MODERN RHEUMATOLOGY
Vol.14 No.2 |
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Genetic epidemiology of psoriatic arthritis
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Pauline Ho1 , Anne Barton1 and Jane Worthington1
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| (1) Arthritis Rheumatism Campaign Epidemiology
Research Unit, ARC-EU, Stopford Building, University of Manchester,
Manchester, M13 9PT, UK |
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| Abstract |
| Psoriatic arthritis (PsA) is defined
as an inflammatory arthritis (IA) associated with psoriasis and is
usually negative for rheumatoid factor. This ambiguous definition
has impeded research into this subject, but as yet no agreed definition
or classification criteria exist for PsA. Furthermore, there are
those who question whether PsA exists as a distinct disease, or is
a mere coincidence of inflammatory arthritides such as rheumatoid
arthritis or ankylosing spondylitis with psoriasis. The pathogenesis
of both IA and psoriasis is complex, involving interactions between
many different genes and environmental etiological factors. It is
likely that PsA is also a complex disease. The identification of
genetic susceptibility factors unique to PsA over and above those
that contribute to IA or psoriasis alone would put an end to speculation
as to whether PsA exists as a distinct disease. In addition, it may
aid in the development of novel therapies which target PsA specifically.
This review summarizes the approaches taken to identify PsA susceptibility
genes, and outlines some interesting regions which may harbor PsA
susceptibility genes. |
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| Key words |
| Genetics - Gene - Psoriatic arthritis (PsA)
- Psoriasis - Review |
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