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MR Vol.14 No.1 indexに戻る
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MODERN RHEUMATOLOGY
Vol.14 No.1 |
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Reiters syndrome following intravesical bacille
biliE de Calmette?GuErin treatment for superficial bladder carcinoma:
report of six cases |
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| Hideyuki Murata1, Yoshihiro Adachi1, Takehiko
Ebitsuka1, Yusuke Chino1, Reiko Takahashi1, Taichi Hayashi1, Daisuke
Goto1, Isao Matsumoto1, Akito Tsutsumi1, Hideyuki Akaza1 and Takayuki
Sumida1 |
(1) Division of Rheumatology, Department of
Internal Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba,
305-8575, Japan
(2) Department of Urology, University of Tsukuba, Tsukuba, Japan |
Received: 18 April 2003 Accepted: 08 August 2003 |
| Abstract |
| Abstract We report the cases of six patients
who developed acute Reiters syndrome following intravesical bacille
biliE de Calmette?GuErin (BCG) immunotherapy for superficial bladder
cancer. After the third to eighth BCG intravesical injection, the
patients developed conjunctivitis, aseptic urethritis, and polyarthritis
consistent with a diagnosis of Reiters syndrome. HLA-B27 antigen
was negative in five of the patients examined. Two of the patients
responded to nonsteroidal anti-inflammatory drugs for polyarthritis,
and the other four responded to steroids (prednisolone 5?10mg/day).
The frequent use of intracavitary BCG may increase the incidence
of BCG-induced Reiters syndrome. Further analysis of the relationship
between HLA-B and -DR alleles and arthritis should shed light on
the mechanism of BCG-induced Reiters syndrome. |
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| Key words |
| Key words Bladder carcinoma - Intravesical bacille
biliE de Calmette?GuErin (BCG) - Reiters syndrome - Therapy |
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