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MR Vol.14 No.1 indexに戻る
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MODERN RHEUMATOLOGY
Vol.14 No.1 |
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Effect of ebselen, a scavenger of reactive oxygen
species, on chondrocyte metabolism
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| Tetsunao Matsushita1, Kanji Fukuda1 , Hironori
Yamamoto1, Kenji Yamazaki1, Takashi Tomiyama1, Masamichi Oh1 and
Chiaki Hamanishi1 |
| (1) Department of Orthopaedic Surgery, Kinki
University School of Medicine, 377-2 Ohno-higashi, Osaka-sayama,
589-8511, Japan |
Received: 26 February 2003 Accepted:
17 June 2003 |
| Abstract |
| Abstract Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one),
a synthetic heterocyclic seleno-organic compound, has been shown
to act as a scavenger of reactive oxygen species (ROS). We have previously
reported that interleukin-1 (IL-1) inhibited proteoglycan (PG) synthesis
and induced the production of ROS in cartilage explants and isolated
chondrocyte cultures. In this study, we report the protective effect
of ebselen against IL-1-mediated inhibition of PG synthesis and ROS
induction in cultured cartilage explants and chondrocytes. Ebselen
also reversed the inhibition of PG synthesis in mechanically stressed
cultured chondrocytes. These data suggest that the use of the antioxidant
ebselen may be a useful tool for studying the mechanisms of cartilage
degradation. |
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| Key words |
Key words Chondrocyte - Ebselen - Interleukin-1
(IL-1) - Nitric oxide - Peroxynitrite
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