 |
MR Vol.13 No.4 indexに戻る
 |
MODERN RHEUMATOLOGY
Vol.13 No.4 |
 |
|
|
 |
|
|
Severe skin ulceration associated with Wegeners
granulomatosis: successful treatment with hyperbaric oxygen and prostaglandin
E1
|
|
|
| Keisuke Nakatsuka1, Kazuyoshi Saito1, Kiyotaka
Kohshi2, Ikuhide Konda2 and Yoshiya Tanaka1 |
(1) First Department of Internal Medicine, University
of Occupational and Environmental Health, School of Medicine, 1-1
Iseigaoka, Yahatanishi-ku, Kita-kyushu, 807-8555, Japan
(2) Division of Hyperbaric Medicine, University of Occupational and Environmental
Health, School of Medicine, Kita-kyushu, Japan |
| |
| Received: 10 August 2002 Accepted: 06 June 2003 |
| |
| Abstract |
| A 36-year-old woman patient with intractable
skin ulcers associated with Wegeners granulomatosis was successfully
cured by combination therapy with hyperbaric oxygenation therapy
(HBO) and intravenous prostaglandin E1 (PGE1). Treatment for 4 months
with prednisolone, intravenous PGE1, and cyclophosphamide did not
result in healing of the multiple skin lesions on her legs. Repeated
HBO with intravenous PGE1 therapy over 6 months resulted in a complete
healing of the skin ulcers. We recommend the use of HBO combined
with PGE1 for severe cutaneous lesions associated with generalized
vasculitis. |
| |
| Key words |
Hyperbaric oxygen therapy (HBO) - Skin ulcer
- Wegeners granulomatosis (WG)
|
|
|
 |
|
|
