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MR Vol.13 No.4 indexに戻る
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MODERN RHEUMATOLOGY
Vol.13 No.4 |
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BehCets disease associated with myelodysplastic
syndrome with elevated levels of inflammatory cytokines
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| Hitoshi Hasegawa1 , Kikue Iwamasa1, Nobuaki Hatta2
and Shigeru Fujita1 |
(1) First Department of Internal Medicine,
Ehime University School of Medicine, Shigenobu, Onsen-gun, Ehime,
791-0295, Japan
(2) Koyo New Town Hospital, Hiroshima, Japan |
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| Received: 11 November 2002 Accepted: 21 April
2003 |
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| Abstract |
| We report the case of a 56-year-old Japanese
woman with BehCets disease and myelodysplastic syndrome (MDS), who
had a history of episodic high-grade fever, recurrent oral and genital
ulcers, and erythema nodosum, during a 13-year period from 1989 to
2002. Bone marrow aspirates obtained in January 1995 showed refractory
anemia with trisomy 8, a subtype of MDS. Her serum levels of soluble
interleukin-2 receptor (IL-2R), interferon-, IL-1, IL-6, IL-8, and
granulocyte?macrophage colony stimulating factor in the active state
were higher than those in the inactive state, whereas those of tumor
necrosis factor- and IL-10 did not increase even in the active state.
In this case, it was speculated that a T-cell immune response might
have been involved in the disease pathogenesis, and that the repeated
febrile episodes might have been a manifestation of neutrophil hyperfunction
induced by increased serum levels of inflammatory cytokines. |
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| Key words |
| BehCets disease - Cytokine - Fever - Myelodysplastic
syndrome (MDS) - Trisomy 8 |
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