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Corticosteroid-resistant multiple colonic ulcers
in a patient with systemic lupus erythematosus/systemic sclerosis
overlap syndrome effectively treated with intravenous cyclophosphamide
pulse therapy |
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| Yasuhiro Ota1 , Norio Nozue2, Yoshiaki Dei1,
Shinichi Kondo1 and Hiroyuki Ohashi1 |
(1) Third Department of Internal Medicine,
Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu,
431-3192, Japan
(2) Department of Internal Medicine, Fujieda Municipal General Hospital, Fujieda,
Japan |
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| Received: 11 November 2002 Accepted: 27 March
2003 |
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| Abstract |
| We report a rare case of a 17-year-old female
with overlap syndrome (systemic lupus erythematosus and systemic
sclerosis) who developed severe abdominal pain and bloody diarrhea
accompanied by central nervous system lupus. Colonoscopy revealed
multiple irregular and linear ulcers throughout the colon, which
were resistant to corticosteroid pulse therapy and plasma exchange.
The patient finally recovered after treatment with a relatively low
dose of monthly intravenous cyclophosphamide (250mg/m2) pulse therapy. |
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| Key words |
| Colonic ulcers - Cyclophosphamide pulse therapy
(IV-CY) - Overlap syndrome - Systemic lupus erythematosus (SLE)
- Systemic sclerosis (SSc) |
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