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Congestive heart failure and axonal polyneuropathy
induced by alfacalcidol in a patient with systemic lupus erythematosus |
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| Hirotoshi Kikuchi1 , Kaori Aramaki1 and Shunsei
Hirohata1 |
| (1) Department of Internal Medicine, Teikyo University
School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan |
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| Received: 22 August 2002 Accepted: 26 December
2002 |
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| Abstract |
| We describe the case of a 29-year-old woman with
systemic lupus erythematosus (SLE), who developed congestive heart
failure and severe axonal polyneuropathy after 9 months of treatment
with alfacalcidol for the prevention of corticosteroid-induced osteoporosis.
There was no evidence for the exacerbation of SLE. Moreover, both
congestive heart failure and axonal polyneuropathy improved after
discontinuation of the alfacalcidol without increasing the dose of
corticosteroid. Since alfacalcidol is commonly used in the prevention
of corticosteroid-induced osteoporosis, rheumatologists should be
aware of the presence of this life-threatening adverse effect. |
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| Key words |
| Corticosteroid - Osteoporosis - Side effects
- Systemic lupus erythematosus (SLE) - Vitamin D |
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