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MR Vol.13 No.2 indexに戻る
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MODERN RHEUMATOLOGY
Vol.13 No.2 |
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| Peripheral nervous system involvement complicated
due to vasculitis in cases of primary Sjogren's syndrome: case studies
in a single hospital and a literature review
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| Yusuke Miwa1, Shigeko Inokuma1, Yoshimi Yokoe1,
Yuko Okazaki1, Takeo Sato1, Reika Maezawa1 |
| （1） Department of Allergy and Immunological
Diseases, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome,
Bunkyo-ku, Tokyo 113-8677, Japan |
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| Abstract |
| To determine the background features of peripheral
nervous system (PNS) involvement in cases of primary Sjogren's
syndrome (SS), we studied the nervous system involvement, mainly
that
of PNS, in patients with primary SS who were admitted to our
hospital during a period of 19 years. Nine of 82 admitted patients
with primary SS had PNS involvement and 12 had central nervous
system (CNS) involvement. Among 182 secondary SS patients, 25
had CNS involvement, and none had PNS involvement. The nine patients
with PNS involvement were older and their disease duration was
shorter than those with CNS involvement and either primary or
secondary SS. Four patients exhibiting active progression of
PNS involvement had concomitant vasculopathy clinically that
was confirmed by nerve or skin biopsy examination, with an increase
in the serum C-reactive protein level. According to the literature,
among 17 reported SS patients with PNS involvement, 13 had primary
SS, and 13 had vasculitis as confirmed by biopsy examination.
Nervous system involvement in cases of SS is not rare. PNS involvement
was observed mostly in elderly patients with primary SS, and
its active progression was concomitant with vasculopathy. |
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| Keywords |
| Peripheral nervous system (PNS) involvement
・ Primary Sjogren's syndrome (SS) ・ Vasculopathy |
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