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MR Vol.13 No.2 indexに戻る
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MODERN RHEUMATOLOGY
Vol.13 No.2 |
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Raised plasma adrenomedullin level in Behcet's
disease patients |
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| Yuki Nanke1, Shigeru Kotake1, Katsunori Ogasawara
, Machiko Shimakawa , Saeko Takasawa , Hiroshi Ujihara , Masao Matsubara
, Yoshitaka Miyanaga , Naoyuki Kamatani1 |
| （１） Institute of Rheumatology, Tokyo Women's
Medical University 10-22 Kawada-cho, Shinjuku-ku, Tokyo 162-0054,
Japan |
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| Abstract |
| To investigate the role of plasma adrenomedullin
(AM) in the pathogenesis of Behcet's disease (BD) patients
with inactive ocular complications or ocular attack, 18 consecutive
BD patients
with
ocular complications, including 1 BD patient with ocular attack,
another group of 6 BD patients with ocular attack, and 10 normal
volunteers were evaluated. All BD patients were regularly followed
at ophthalmic outpatient clinics. Levels of both total and mature
AM in plasma were measured by immunoradiometric assay. Plasma
levels of endothelin-1 (ET-1) were also measured by radioimmunoassay.
We also measured the levels of C-reactive protein (CRP) in plasma.
Levels of total AM in plasma (mean ± SD, 19.6 ± 6.9?fmol/l) were
significantly higher in BD patients than in normal volunteers
(14.5 ± 3.6?fmol/l) (P = 0.01). The levels of mature
AM were also higher in BD patients (1.6 ± 0.4?fmol/l) than in
normal volunteers (0.3 ± 0.6?fmol/l) (P = 0.002).
The levels of AM in patients with ocular attack were higher than
those in normal volunteers, although there was no significant
difference compared to levels of AM in BD patients without ocular
attack. AM may play an important role as an antiinflammation
factor or may reflect endothelial damage as a marker of disease
activity in BD patients. |
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