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MR Vol.13 No.2 indexに戻る
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MODERN RHEUMATOLOGY
Vol.13 No.2 |
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Systemic lupus erythematosus and human endogenous
retroviruses |
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| Iwao Sekigawa1, Hitoshi Ogasawara , Toshio
Naito , Hiroshi Kaneko , Takashi Hishikawa , Hiroshi Hashimoto |
| （1） Department of Medicine, Juntendo University
Izu-Nagaoka Hospital, 1129 Nagaoka, Izu-Nagaoka-cho, Tagata-gun,
Shizuoka 410-2295, Japan |
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| Abstract |
| Human endogenous retroviruses (HERV)
are known to be widely present in the human genome. Several investigations
have suggested a
possible etiological role of HERV in certain human disorders,
including systemic lupus erythematosus (SLE). Here we review
and discuss the possible role of HERV, especially HERV clone
4-1, in the onset of SLE, based on recent findings including
our own data. |
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