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MR Vol.13 No.1 indexに戻る
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MODERN RHEUMATOLOGY
Vol.13 No.1 |
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Myositis in primary Sjogren's syndrome: clinical
and pathological report |
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| A. Aoki1, S. Ono A1, A. Ueda1, E. Hagiwara1,
T. Tsuji1, M. Misumi1, H. Ideguchi1, Y. Takeda1, Y. Ishigatsubo1 |
| (1) Internal Medicine, Yokohama City University,
School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004,
Japan |
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| Abstract |
| Abstract To clarify the clinical features of
myositis complicated with primary Sjogren's syndrome (SS), we studied
89 patients with Sjogren's syndrome (one male and 88 females; mean
age 56.0 - 15.31 years). Myositis was diagnosed from clinical findings,
muscle enzymes, electromyographic findings, and muscle biopsy findings.
Myositis was diagnosed in 5 of 89 SS patients (5.6%). One patient
developed myositis 7 months after the onset of SS. The other four
patients were diagnosed with myositis and SS simultaneously. Muscular
weakness was mild and slowly progressive over 4-14 months (mean 8.4
months). All patients were able to walk without any assistance at
the start of prednisolone therapy. Muscular enzymes were slightly
elevated (from 1.5- to 12-fold). All patients tested negative for
anti-Jo1 antibody and tested positive for antinuclear antibody. Anti-Ro(SSA)
antibody was positive in 4/5 (90%); anti-La(SSB) was positive in
2/5 (40%). Although the clinical features of all patients met the
criteria for polymyositis of Bohan, they responded well to small
or moderate doses of prednisolone, which could be decreased without
a recurrence of muscular weakness in all patients. Myositis with
Sjogren's syndrome showed relatively moderate symptoms and responded
well to prednisolone. A prospective follow-up of patients may provide
further information. |
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| Key words |
| Key words Myositis ・ Polymyositis ・ Prednisolone
・ Primary Sjogren's
syndrome (SS) |
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