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MR Vol.13 No.1 indexに戻る
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MODERN RHEUMATOLOGY
Vol.13 No.1 |
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Evaluation of Kampo medicines used to treat rheumatoid
arthritis in collagen-induced arthritic and pX transgenic mice |
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| Y. Ono1, Y. Ogihara1, S. Saijo2, Y. Iwakura2,
M. Inoue1 |
(1)Laboratory of Pharmacognosy, Graduate School
of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori,
Mizuho-ku, Nagoya 467-8603, Japan
(2)
Center of Experimental Medicine,
Institute of Medical Science, University of Tokyo, Tokyo, Japan |
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| Abstract |
| Abstract To evaluate the usefulness of Kampo
medicines (traditional herbal medicines) used clinically for the
treatment of rheumatoid arthritis (RA), we selected eight of them
and examined their effects on collagen-induced arthritic and pX
transgenic mice. Among these, Dai-bofu-to, Kanzo-bushi-to, and
Makyo-yokkan-to significantly reduced the severity of arthritis
in collagen-induced arthritis (CIA) mice. The onset of arthritis
was delayed by three Kampo medicines, but only the effect of Makyo-yokkan-to
was statistically significant. In addition, three Kampo medicines
suppressed the arthropathy of pX transgenic mice, which had developed
spontaneously. The onset of arthritis was delayed by 10.7, 8.3,
and 15.4 days following treatment with Dai-bofu-to, Kanzo-bushi-to,
and Makyo-yokkan-to, respectively. A study of the underlying mechanism
showed that Kanzo-bushi-to decreased serum antitype II collagen
antibody levels, suggesting that Kanzo-bushi-to possesses immunomodulating
activity. This study shows that some Kampo medicines are effective
in an induced or spontaneously developed arthritis animal model
of human RA. |
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| Key words |
| Key words Collagen-induced arthritis (CIA) ・
Immuno-regulation ・ Kampo medicines ・ pX transgenic mouse ・ Rheumatoid
arthritis
(RA) |
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