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MR Vol.13 No.1 indexに戻る
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MODERN RHEUMATOLOGY
Vol.13 No.1 |
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Endothelial cell-binding antibodies in patients
with systemic lupus erythematosus |
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| H. Bando1, N. Tamura1, S. Kobayashi1, M.
Ohyanagi Hara2, Y. Ichimura3, M. Tajima1, K. Haruta1, H.
Hashimoto1 |
(1)Department of Rheumatology and Internal Medicine,
Juntendo University, School of Medicine, 2-1-1 Hongo, Bunkyo-ku,
Tokyo
(2) Division of Biochemistry, Central Laboratory for Medical Science, Juntendo
University, School of Medicine, Tokyo, Japan
(3)
Department of Molecular Biology,
Toho University, School of Science, Narashino,
Japan |
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| Abstract |
| Abstract The implications of endothelial cell-binding
IgG antibodies (EC IgG) in systemic lupus erythematosus (SLE) was
evaluated by determining level of EC IgG in sera from 112 SLE patients.
The serum EC IgG level was determined by the cyto-ELISA method using
human umbilical vein endothelial cells (HUVEC), human microvascular
endothelial cells (HMVEC), and aortic endothelial cells (HAEC) as
antigens. The levels of EC IgG were significantly higher among patients
with SLE than among healthy control subjects (P < 0.001), and
68% (76/112) of SLE patients were shown to be EC IgG-positive. In
patients with active lupus nephritis, the level of EC IgG was statistically
and significantly elevated compared with those without lupus nephritis
(P < 0.05). Negative correlations between EC IgG level and levels
of CH50, C3, and lymphocyte count were revealed (P < 0.05, P < 0.005,
and P < 0.05, respectively). When clinical course was evaluated,
the levels of EC IgG correlated with disease activity. Definitive
correlations in antibody levels between HUVEC and HMVEC, and between
HUVEC and HAEC were revealed (both P < 0.0001). The results of
this study revealed that the EC IgG in patients with SLE was involved
in the onset of clinical manifestation, especially in patients with
active lupus nephritis. |
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| Key words |
| Key words Antiendothelial antibodies ・ Endothelial
cell-binding antibodies ・ Lupus nephritis ・ Systemic lupus erythematosus
(SLE) |
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