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MR Vol.13 No.1 indexに戻る
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MODERN RHEUMATOLOGY
Vol.13 No.1 |
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IgG and IgA antibody titers against human
heat-shock protein (hsp60) in sera of rheumatoid arthritis and
osteoarthritis
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| S. Watanabe1, N. Takubo2, I. Hirai3, Y.
Hitsumoto4 |
(1)Department of Orthopaedic Surgery, Ehime University
School of Medicine, Shitsukawa Shigenobu-cho, Onsen-gun, Ehime 791-0295,
Japan
(2) Center for Rheumatic Diseases, Matsuyama Red Cross Hospital, Matsuyama, Japan
(3) H. Lee Moffitt Cancer Center and Research Institute, University of South
Florida
College of Medicine, FL, USA
(4) Department of Biochemistry, Okayama University of Science, Okayama, Japan |
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| Abstract |
| Abstract To learn whether heat-shock proteins
(HSP) are involved in the pathogenesis of rheumatoid arthritis (RA),
antirecombinant human heat-shock protein 60 (hsp60) IgG and IgA in
sera of RA and osteoarthritis (OA) patients were investigated. Only
the anti-hsp60 IgG titer of seropositive (RF-positive) patients was
found to be elevated. Although RF titers of the sera of seropositive
RA patients were increased, there was no correlation between the
individual anti-hsp60 IgG titer and the corresponding RF titer. In
contrast, all the anti-hsp60 IgA titers of the sera of OA, seronegative
RA, and seropositive RA patients were found to be elevated. Among
them, only the serum IgA concentration of seropositive RA patients
was increased. Thus, it was suggested that the increased anti-hsp60
IgG reflects the pathogenesis of RA and its activity. It was also
suggested that the increased anti-hsp60 IgA response reflects an
involvement of hsp60 in the pathogenesis of arthritides rather than
the pathogenesis of RA. |
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| Key words |
| Key words Heat-shock protein (HSP) ・ IgA ・ Rheumatoid arthritis
(RA) |
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