 |
MR Vol.13 No.1 indexに戻る
 |
MODERN RHEUMATOLOGY
Vol.13 No.1 |
 |
|
|
 |
|
|
Antibodies to type II collagen and their association with HLA DR1 alleles in Japanese patients with rheumatoid arthritis |
|
|
| Y. Ohnishi1, A. Tsutsumi1 and T. Sumida1 |
| (1) Internal Medicine, Yokohama City University, School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan |
| |
| Abstract |
| To investigate whether immunological responses to type II collagen (CII) play an important role in the pathogenesis of rheumatoid arthritis (RA), the presence of anti-CII antibodies was examined by enzyme immunoassay in 130 Japanese patients with RA, 10 systemic lupus erythematosus (SLE) patients, and 30 healthy subjects. In addition, the HLA-DRB1 genes of 40 RA patients were determined, and their association with positive findings of anti-CII antibodies was examined. A significantly high frequency of positive findings of anti-CII antibodies was detected in sera from RA patients (19%, P < 0.05) in comparison with that in sera from healthy subjects (3%). High frequencies of DRB1*0405 and 0101 alleles were observed in the 40 RA patients examined (40.0% and 30.0%, respectively). Patients with DRB1*0101 had a significantly higher rate of positive findings of anti-CII antibodies than those without DRB1*0101 (66.7% and 28.6%, respectively, P < 0.05). No such association was observed for DRB1*0405. From these findings, we suggest that immunological responses to CII may play an important role in the development of arthritis in some RA patients. |
| |
| Key words |
| Antibody - HLA - Rheumatoid arthritis (RA) - Type II collagen (CII) |
|
|
 |
|
|
