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MR Vol.12 No.4 indexに戻る
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MODERN RHEUMATOLOGY
Vol.12 No.4 |
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Dramatic efficacy of cyclophosphamide pulsed
therapy combined with double-filtration plasmapheresis for treating
severe massive pulmonary hemorrhage associated with systemic lupus
erythematosus |
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| T. Ito1, K. Inose1, S. Horie1, Y. Okubo1, R.
Yoshida1, K. Nakazawa1, K. Nakada1 |
| (1)Department of Internal Medicine, Saiseikai
Utsunomiya Hospital, 911-1 Takebayashi, Utsunomiya 321-0974, Japan |
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| Abstract |
| Abstract Pulmonary hemorrhage (PH) is a rare
but fatal complication of systemic lupus erythematosus (SLE). We
report a patient with SLE and a massive PH who was treated with double-filtration
plasmapheresis synchronized with cyclophosphamide pulsed therapy.
The patient showed dramatic improvement immediately and was followed
for 3 years without recurrence. Prompt treatment during the acute
phase of PH with this short-term intensive combination therapy may
offer the best chance of success. There are few reports of long-term
followup, especially in Japan. |
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| Key words |
| Key words Cyclophosphamide pulsed therapy
・ Double-filtration plasmapheresis (DFPP) ・ Plasma exchange ・ Pulmonary
hemorrhage
(PH) ・ Systemic lupus erythematosus (SLE) |
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