 |
MR Vol.12 No.4 indexに戻る
 |
MODERN RHEUMATOLOGY
Vol.12 No.4 |
 |
|
|
 |
|
|
Mechanisms of anti-DNA antibody production |
|
|
| T. Kubota1 |
| (1) Tokyo Medical and Dental University Graduate
School of Allied Health Sciences, 1-5-45 Yushima, Bunkyo-ku, Tokyo
113-8519, Japan |
| |
| Abstract |
| Abstract The nucleosome has attracted attention
because it is a possible primary antigen that initiates autoimmune
reactions and also seems to play a key role in glomerular injury
in systemic lupus erythematosus (SLE). It is not immunogenic in nonautoimmune
individuals, however, and many other protein or peptide antigens
inducing anti-DNA antibodies in normal animals have been reported
recently. Various mechanisms have been proposed to account for this,
including idiotype-anti-idiotype, hapten-carrier, molecular mimicry,
and others. In addition to the initial immune responses to such antigens,
breakdown of self-tolerance influenced by genetic factors or hormonal
dysregulation may be necessary preconditions for occurrence of the
disease. |
| |
| Key words |
| Key words Anti-DNA antibodies ・ Systemic lupus
erythematosus (SLE) ・ DNA-binding protein ・ Molecular mimicry ・ Idiotypic
network |
|
|
 |
|
|
