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MR Vol.12 No.4 indexに戻る
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MODERN RHEUMATOLOGY
Vol.12 No.4 |
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Rheumatoid arthritis: new insights into
the role of synovial inflammation in joint destruction |
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| M. D. Smith1, P. P. Tak2 |
(1)Department of Medicine, Flinders Medical
Centre and Repatriation General Hospital, Adelaide, Australia
(2)Division of Clinical Immunology and Rheumatology, F4-218 Academic Medical
Center/University of Amsterdam, P.O. Box 22700, 1100 DE Amsterdam, The Netherlands |
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| Abstract |
| Abstract Rheumatoid arthritis (RA) is characterized
by inflammation and proliferation of synovial tissue, leading to
degradation of articular cartilage and bone with functional impairment
as a result. It has recently become clear that early suppression
of synovial inflammation is essential in preventing progressive
joint destruction, although inflammation and destruction are in
part uncoupled. New insights into the role of matrix metalloproteinases
(MMPs), aggrecanase, granzyme B, receptor activator of nuclear
factor 3B (RANK)-receptor activator of nuclear factor 3B ligand
(RANKL) interaction, and other factors involved in joint destruction
may lead to the development of novel therapies aimed at specific
inhibition of cartilage and bone degradation. |
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| Key words |
| Key words Aggrecanase ・ Granzyme ・ Matrix
metalloproteinases (MMPs) ・ Osteoprotegerin (OPG) ・ Receptor activator
of nuclear factor &kgr;B
ligand (RANKL) ・ Rheumatoid arthritis (RA) |
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