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MR Vol.12 No.3 indexに戻る
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MODERN RHEUMATOLOGY
Vol.12 No.3 |
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Prospective study of a systemic sclerosis/dermatomyositis
overlap patient presenting with anti-Ku and anti-Ki antibodies |
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| K. Miyachi1, R. W. Hankins2, T. Mimori3,
Y. Okano4, M. Akizuki4 |
(1)Keigu Clinic, 2-2 Ichibanishinaka-cho,
Tsurumi-ku, Yokohama 230-0023, Japan
(2)First Diagnostic Division, Health Sciences Research Institute, Yokohama,
Japan
(3)Kyoto University, Graduate School of Medicine, Department of Rheumatology
and Clinical Immunology, Kyoto, Japan
(4)Department of Internal Medicine, Yokohama Municipal Hospital, Yokohama,
Japan |
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| Abstract |
| Abstract A 60-year-old woman visited the Keigu
Clinic in January 1998 complaining of morning stiffness and flexion
contracture of the distal interphalangeal joint. Blood tests showed
the presence of antinuclear antibody at a 1 : 40 dilution with
speckled staining. She was suspected of having Heberden's node.
Nine months later, she developed Raynaud's phenomenon, sclerodactyly,
and Gottron's sign, and was diagnosed with systemic sclerosis/dermatomyositis
(SSc/DM) overlap. Blood tests revealed the presence of antinuclear
antibody at a 1 : 5120 dilution, along with high titer of anti-Ku
and anti-Ki antibodies. Subsequently, the patient developed interstitial
pneumonia in January 2000. It is thought that the appearance of
antinuclear antibody and development of other immunological events
played an important role in determining this patient's limited
SSc/DM overlap. |
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| Key words |
| Key words Anti-Ku antibody ・ Immunoprecipitation
・ Prospective study ・ Systemic sclerosis/dermatomyositis (SSc/DM)
overlap |
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