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MR Vol.12 No.3 indexに戻る
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MODERN RHEUMATOLOGY
Vol.12 No.3 |
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A male patient who developed late-onset primary
biliary cirrhosis presenting with antinuclear envelope antibodies |
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| K. Miyachi1, T. Horigome2, Y. Matsuoka3,
S. Irimajiri3, M. Shibata4, K. Asada5, R. W. Hankins6 |
(1)Keigu Clinic, 2-2 Ichibanishinaka-cho, Tsurumi-ku,
Yokohama 230-0023, Japan
(2)Department of Biochemistry and Biology, Faculty of Science, Niigata University,
Niigata, Japan
(3)Department of Internal Medicine, Kawasaki Municipal Hospital, Kawasaki, Japan
(4)Second Department of Internal Medicine, Showa University School of Medicine,
Tokyo, Japan
(5)Department of Oral and Maxillofacial Surgery, Tsurumi University School of
Dental Medicine, Yokohama, Japan
(6)First Diagnostic Division, Health Sciences Research Institute, Yokohama, Japan |
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| Abstract |
| Abstract An 81-year-old man who had previously
shown high levels of alkaline phosphatase (ALP), %-glutamyltransferase
(GTP), and total bilirubin presented with acute liver damage. He
was positive for serum anti-gp210 and anti-p62 antibodies, but
negative for serum antimitochondrial antibody. A liver biopsy revealed
massive interstitial fibrosis and pseudolobulus, which were compatible
with a diagnosis of primary biliary cirrhosis (PBC) at Scheuer's
stage 4. He was given ursodeoxycolic acid at 600 mg/day. However,
his condition deteriorated, and he eventually died of hepatic insufficiency
in a state of malnutrition. We hypothesize that the presence of
anti-gp210 and anti-p62 complex protein antibodies, rather than
that of antimitochondrial antibodies, was correlated with the progression
of PBC in this particular case. |
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| Key words |
| Key words Anti-gp210 antibody ・ Antinuclear
envelope antibody (ANEA) ・ Anti-p62 complex antibody ・ Primary
biliary cirrhosis
(PBC) ・ Sjogren's syndrome (SS) |
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