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MR Vol.12 No.3 indexに戻る
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MODERN RHEUMATOLOGY
Vol.12 No.3 |
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ACTH expression in synovium of patients
with rheumatoid arthritis and Lewis rats with adjuvant arthritis |
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| S. Miyazaki1, T. Yoshikawa1, A. Hashiramoto1,
R. Yamada1, Y. Tsubouchi1, M. Kohno1, Y. Kawahito1, M. Kondo1, H.
Sano1 |
| (1)First Department of Internal Medicine, Kyoto
Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto
602-8566, Japan |
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| Abstract |
| Abstract Adrenocorticotropic hormone (ACTH)
and another pro-opiomelanocortin-derived neuropeptide, #-endorphin
(#-End), are stimulated by corticotropin-releasing hormone (CRH)
at the anterior pituitary. CRH and #-End have predominantly proinflammatory
effects in peripheral inflammatory sites. We have supposed that
inflammatory stimuli develop ACTH as well as #-End. In this study,
we investigated the expression of ACTH in inflamed synovial tissue
from patients with rheumatoid arthritis (RA) and osteoarthritis
(OA), and at inflammatory joints with adjuvant-induced arthritis
(AA) in female Lewis (LEW/N) rats. The expression of ACTH immunostaining
was significantly greater in synovium of RA patients than in that
of OA patients (P < 0.0001), and correlated with the extent
of inflammatory mononuclear cell infiltration. Extensive and intense
intracellular ACTH immunostaining, which correlated with the advance
in arthritis score, was observed in the synovial lining layer,
inflammatory mononuclear cells, and fibroblast-like cells of synovium
and chondrocytes in LEW/N rats with AA. In addition, we performed
double immunostaining of the same sections from arthritic joints
in rats with anti-ACTH and anti-CRH antibodies. ACTH and CRH colocalized
in inflammatory mononuclear cells and fibroblast-like cells. ACTH
may play a role in the pathogenesis of RA as well as CRH. |
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| Key words |
| Key words Adjuvant arthritis ・ Adrenocorticotropic
hormone (ACTH) ・ Corticotropin releasing hormone (CRH) ・ Lewis
rat ・ Rheumatoid
arthritis (RA) |
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