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MR Vol.12 No.3 indexに戻る
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MODERN RHEUMATOLOGY
Vol.12 No.3 |
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Subclinical Sjogren's syndrome and anti-Ro/SSA-positive
autoimmune fatigue syndrome in children |
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| Y. Itoh1, T. Imai1, O. Fujino1, T. Igarashi1,
Y. Fukunaga1 |
| (1) Department of Pediatrics, Nippon Medical
School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8605, Japan |
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| Abstract |
| Abstract Although Sjogren's syndrome (SS) is
quite rare among children, subclinical conditions without any sicca
symptoms have been reported. This condition is characterized by nonspecific
rheumatic symptoms and histopathological findings in salivary glands
which are equivalent to SS. Many children with subclinical SS are
positive for anti-Ro/SSA. On the other hand, autoimmune fatigue syndrome
(AIFS) is characterized by chronic nonspecific complaints and positive
antinuclear antibodies, with or without fulfilling the criteria for
chronic fatigue syndrome. Although a novel autoantibody against a
62 kD nuclear protein (anti-Sa) is detected in about 40% of AIFS
patients, few marker antibodies for autoimmune diseases, such as
anti-DNA, anti-Sm, anti-U1-ribonucleoprotein (RNP), or anticardiolipin,
are found in AIFS patients. In this study, however, anti-Ro/SSA was
detected in sera from 8 out of 122 AIFS patients. Seven of the 8
anti-Ro/SSA-positive patients were female. All 8 patients had fatigue
and low-grade fever, but none complained of xerosis. Western immunoblot
analysis revealed that 7 sera reacted with Ro52, and that none was
positive for anti-La/SSB or anti-Sa. Two of the 8 patients had histories
of recurrent parotitis. Lip biopsies showed mild chronic inflammation
compatible with subclinical SS in these 2 patients, although the
other 6 patients had no abnormal histopathology. Thus, at least some
anti-Ro/SSA-positive patients could be diagnosed as having SS. |
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| Key words |
| Key words Antinuclear antibodies (ANA) ・ Anti-Ro/SSA
・ Autoimmune fatigue syndrome (AIFS) ・ Chronic fatigue syndrome
(CFS) ・ Sjogren's
syndrome (SS) |
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