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MR Vol.12 No.2 indexに戻る
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MODERN RHEUMATOLOGY
Vol.12 No.2 |
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Reactive arthritis after pharyngeal infection:
report of two siblings |
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| J. Asakawa A1, Y. Torikoe , I. Kondo A1, M. Yasuda
A2, S. Kobayashi A3, H. Hashimoto A3 |
(1)Department of Medicine, Yanagibashi Hospital,
2-20-4 Yanagibashi, Taito-ku, Tokyo 111-0052, Japan
(2)Department of Medicine, Nakaizu spa Hospital, Tagata-gun, Shizuoka, Japan
(3)Department of Rheumatology, Juntendo University, School of Medicine, Tokyo,
Japan |
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| Abstract |
| Abstract In this report we describe the cases
of two siblings with reactive arthritis (ReA) induced by pharyngeal
infections. The patients were a man and his sister living with
their parents. He developed arthritis in August 1997, and his younger
sister developed similar symptoms in September 1998. Their disease
conditions were both severe and required hospitalization. Their
conditions improved with the administration of nonsteroidal anti-inflammatory
drugs together with antibiotics, and both fully recovered within
1-2 weeks. Rheumatic fever was ruled out since streptococcal infections
were not demonstrated with antistreptolysin O (ASO) or antistreptokinase
(ASK) titers, or with pharyngeal culture. The sister suffered from
a rash which was similar to erythema nodosum on her lower extremities,
but neither chorea nor carditis was observed. Both human leukocyte
antigen (HLA) typing analyses revealed positive results for HLA-B40
and -B39 for the brother and sister, respectively. Both HLA-B40
and -B39 are considered to be related to HLA-B27-negative ReA,
most likely poststreptococcal reactive arthritis (PSRA). Therefore,
the two patients were tentatively diagnosed as suffering from PSRA. |
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| Key words |
| Key words Group-A streptococcal infection
・ Human leukocyte antigen (HLA)-B27, 39, 40 ・ Human leukocyte antigen
(HLA) typing ・ Reactive
arthritis (ReA) |
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