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MR Vol.12 No.2 indexに戻る
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MODERN RHEUMATOLOGY
Vol.12 No.2 |
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Multicentric reticulohistiocytosis with
hydrarthrosis in both knee joints: disease stabilization with synovectomy,
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medication with a steroid and low-dose methotrexate |
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| A. Sakamoto1, R. Nagamine1, T. Maeda1,
T. Shuto1, G. Hirata1, Y. Nakashima1, S. Matsuda1, Y. Iwamoto1 |
| (1)Department of Orthopaedic Surgery, Graduate
School of Medical Sciences, Kyushu University, 3-1-1 Maidashi,
Higashi-ku, Fukuoka 812-8582, Japan |
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| Abstract |
| Abstract Multicentric reticulohistiocytosis
is a rare systemic disease characterized by the infiltration of
histiocytes and multinucleated giant cells with cutaneous nodules,
and severe destructive arthritis. It is commonly the peripheral
joints which are affected, and therefore symptoms in large joints
have not been fully investigated. We describe the case of a 44-year-old
woman with multicentric reticulohistiocytosis, who was suffering
from swelling in both knee joints and cutaneous nodules, in addition
to arthritis in the elbow, hip, and peripheral joints. Magnetic
resonance imaging of both knee joints showed hydrarthrosis associated
with a tumor-like overgrowth of synovial tissue. These symptoms
were reduced following a resection of the synovial tissue and subsequent
medication with prednisone and low-dose methotrexate. It should
be noted that swelling in the knee joints can be one of the symptoms
caused by multicentric reticulohistiocytosis, in addition to cutaneous
nodules and arthritis in the peripheral joints. Resection of synovial
tissue, and medication with prednisone and low-dose methotrexate
were effective in the present case. |
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| Key words |
| Key words Hydrarthrosis ・ Knee ・ Methotrexate
・ Multicentric reticulohistiocytosis ・ Prednisone |
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