 |
MR Vol.12 No.1 indexに戻る
 |
MODERN RHEUMATOLOGY
Vol.12 No.1 |
 |
|
|
 |
|
|
Wnt signaling in rheumatoid synoviocyte activation |
|
|
| M. Sen1, D. A. Carson2 |
(1)Department of Medicine, University of California
at San Diego, La Jolla, CA 92093, USA
(2)Department of Medicine and Sam & Rose Stein Institute for Research on
Aging, UCSD, La Jolla, CA, USA |
| |
| Abstract |
| Abstract Rheumatoid arthritis (RA) is a joint-specific
disease with complex pathogenesis. It is characterized by synovial
inflammation, cartilage loss, and joint destruction. The reasons
why joint damage recurs when therapy is discontinued are not clearly
understood. Several lines of evidence suggest that cartilage damage
is promoted by the transformed and invasive fibroblast-like synoviocytes
(FLS) of the rheumatoid joint. It has been demonstrated in several
systems that aberrant wnt-mediated signaling causes blockade of cartilage
differentiation and malformation of joints. In this review, we have
discussed the importance of wnt?frizzled-mediated signaling in the
autonomous activation of FLS in patients with RA. Anti-wnt/anti-frizzled
antibodies, frizzled receptor antagonists, or small molecule inhibitors
of wnt?frizzled signaling might be useful for therapeutic interventions
in RA. |
| |
| Key words |
| Key words Arthritis ・ Frizzled ・ Synoviocyte
・ Wnt |
|
|
 |
|
|
