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MR Vol.11 No.4 indexに戻る
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MODERN RHEUMATOLOGY
Vol.11 No.4 |
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Hereditary protein S deficiency associated
with rheumatoid arthritis: a case report of pulmonary embolism
after total
hip arthroplasty |
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| M. Nagashima1, S. Ishigami1, S. Kakumoto1, T.
Matsuoka1, T. Ishiwata2, G. Asano2, S. Yoshino1 |
(1)Department of Joint Disease and Rheumatism,
Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603,
Japan
(2) Department of Pathology, Nippon Medical School, Tokyo, Japan |
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| Abstract |
| Abstract A 57-year-old woman with RA of 10
years' duration presented with a history of right coxalgia. Three
weeks after total hip arthroplasty, the patient developed an acute
pulmonary embolism. The results of screening for hypercoagulable
states revealed a protein S (PS) deficiency, and all PS values,
i.e., total PS antigen, free PS antigen, and PS cofactor, were
lower than the normal ranges, showing that the patient had type
I PS deficiency. She had no past history of embolism or deep venous
thrombosis. The values of three PS-related parameters were also
lower than normal in her daughter. The responsible mutation may
be located on exon 15 of genomic PS DNA, as indicated by polymerase
chain reaction. We therefore diagnosed hereditary PS deficiency. |
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| Key words |
| Key words Hereditary protein S deficiency
・ Pulmonary embolism ・ Rheumatoid arthritis (RA) |
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