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MR Vol.11 No.4 indexに戻る
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MODERN RHEUMATOLOGY
Vol.11 No.4 |
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Human parvovirus B19 infection mimicking systemic
lupus erythematosus |
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T. Saeki1, M. Shibuya2, H. Sawada3,
S. Miyamura1, M. Nakano3, F. Gejyo3, M. Arakawa3
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(1)Department of Medicine, Nagaoka Red Cross
Hospital, 297-1 Terajima-machi, Nagaoka 940-2085, Japan
(2)Department of Dermatology, Nagaoka Red Cross Hospital, Nagaoka, Japan
(3)Department of Medicine (II), Niigata University School of Medicine, Niigata,
Japan |
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| Abstract |
| Abstract Although several recent reports have
discussed the similarities between human parvovirus B19 (HPV-B19)
infection and systemic lupus erythematosus (SLE), the relationship
between these conditions has not been established owing to the small
number of patients investigated. In 1998?1999, an outbreak of Erythema
infectiosum occurred close to our hospital, enabling us to investigate
the clinical, hematological, and serological findings, including
serum complement and antinuclear antibodies (ANA), in 22 patients
with acute HPV-B19 infection. The principal symptoms included rash
(86.3%), edema (59%), arthralgia (45.4%) and fever (31.8%). Lymphadenopathy
was seen in three of the 22 cases. The laboratory findings showed
high incidences of leukopenia (50%), hypocomplementemia (95%), and
ANA (64.7%). At the time of disease onset, patients with acute HPV-B19
infection presented with features which were similar to those of
SLE. The possibility of HPV-B19 infection should therefore be considered
in patients presenting with SLE-like features. |
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| Key words |
| Key words Antinuclear antibodies ・ Hypocomplementemia
・ Parvovirus B19 ・ Systemic lupus erythematosus (SLE) |
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