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MR Vol.11 No.4 indexに戻る
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MODERN RHEUMATOLOGY
Vol.11 No.4 |
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Analysis of the levels of endotoxin and #-d-glucan
in the synovial fluid of hemodialysis patients |
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| E. Shiota1, M. Maekawa2, T. Kono3 |
(1)Department of Orthopaedic Surgery, Chikushi
Hospital, Fukuoka University, 377-1 Ohaza-Zokumyoin, Chikushino,
Fukuoka 818-8502, Japan Tel. +81-92-921-1011; Fax +81-92-928-0856
e-mail: ejshiota@orange.ocn.ne.jp
(2)Department of Orthopaedic Surgery, Kyushu Rousai Hospital, Kitakyushu,
Japan
(3)Central Research Laboratories, Seikagaku Corporation, Tokyo, Japan |
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| Abstract |
| Abstract We analyzed the levels of endotoxin
and #-d-glucan, which possibly induce cytokine production, in the
synovial fluid of patients on long-term hemodialysis and compared
the results to those in patients with osteoarthritis and rheumatoid
arthritis. We studied 42 knees in 42 hemodialysis patients, 21 in
21 osteoarthritis patients, and 26 in 26 rheumatoid arthritis patients.
The mean ages were 60.7, 63.2, and 59.7 years, respectively. The
duration of hemodialysis in the long-term hemodialysis group averaged
14.0 years. The concentrations of endotoxin and #-d-glucan in the
synovial fluid of these three groups were measured. The concentration
of endotoxin was the same in the three groups. However, the concentration
of #-d-glucan was significantly higher in long-term hemodialysis
patients. This finding suggests that #-d-glucan may have some relation
to the pathogenesis of the synovitis which exists in the hydrarthrosis
of long-term hemodialysis patients. |
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| Key words |
| Key words Endotoxin ・ &bgr;-
d -glucan ・ Hemodialysis ・ Synovial fluid |
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