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MR Vol.11 No.4 indexに戻る
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MODERN RHEUMATOLOGY
Vol.11 No.4 |
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Effects of FR167653, a dual inhibitor of interleukin-1
and tumor necrosis factor, on adjuvant arthritis in rats |
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| T. Shinozaki1, K. Takagishi1, S. Tsutsumi1,
T. Yanagawa1, K. Takeuchi1, H. Watanabe1, T. Fukuda2 |
(1)Department of Orthopedic Surgery, Gunma University
Faculty of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511, Japan
(2)Department of Laboratory Sciences and Pathology, Gunma University School of
Health Sciences, Maebashi, Japan |
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| Abstract |
| Abstract The effects of FR167653, a dual inhibitor
of interleukin (IL)-1# and tumor necrosis factor (TNF)-! production,
on the development of adjuvant arthritis were investigated in rats.
Female Sprague?Dawleys rats weighing 130 g with adjuvant arthritis
were administered FR167653 0.1, 1, 10, or 30 mg/kg, and their arthritis
scores, soft tissue X-rays, and histological findings were then compared
with those of a control group. Body weights were also recorded. FR167653
suppressed the severity of adjuvant arthritis in a dose-dependent
manner. Administration of the drug had little effect on body weight.
FR167653 might locally affect arthritic joints to prevent inflammation.
However, further experiments are necessary to elucidate the underlying
mechanisms. |
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| Key words |
| Key words Adjuvant arthritis ・ Cytokine ・
Cytokine suppressive agent ・ FR167653 |
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