 |
MR Vol.11 No3 indexに戻る
 |
MODERN RHEUMATOLOGY
Vol.11 No.3 |
 |
|
|
 |
|
|
Menopausal syndrome in female patients with rheumatoid
arthritis |
|
|
| R. Nagamine A1, T. Maeda A2, T. Shuto A2, Y.
Nakashima A2, G. Hirata A2, Y. Iwamoto A2 |
(1)Department of Orthopaedic Surgery, Kyushu
Rosai Hospital, 1-3-1 Kuzuharatakamatsu, Kokuraminami-ku, Kitakyushu
800-0296,
Japan
(2)Department of Orthopaedic Surgery, Graduate School of Medical
Science, Kyushu University, Fukuoka, Japan |
| |
| Abstract |
| Abstract This study was performed to assess the
relationship between joint symptoms in rheumatoid arthritis (RA)
and symptoms in menopausal syndrome. Detailed analyses of the clinical
course, laboratory data, joint symptoms, and symptoms of menopausal
syndrome were performed for five patients with stage I and monocyclic-type
RA. The age when joint symptoms first appeared coincided with the
age of menopause in all patients, and the mean age was 51.0 years.
The mean period from menopause to this study was 5.4 years. All patients
showed more than six menopausal syndrome symptoms. Two patients were
confirmed gynecologically to have definite menopausal syndrome, and
accordingly hormone replacement therapy (HRT) was given. In one patient,
the polyarthralgia disappeared after she received HRT. All the American
College of Rheumatology (ACR) criteria, with the exception of subcutaneous
nodules, can be explained as symptoms related to estrogen deficiency
in menopausal syndrome because estrogen regulates the production
of inflammatory cytokines such as IL-1, IL-6, and TNF!, and these
cytokines are produced in greater abundance in conditions of estrogen
deficiency. Estrogen deficiency at the menopause influences joint
symptoms and inflammatory parameters in rheumatoid arthritis. Estrogen
deficiency in menopausal syndrome may induce joint symptoms resembling
RA. |
| |
| Key words |
| Key words Diagnostic criteria ・ Estrogen ・
Interleukin ・ Menopausal syndrome ・ Rheumatoid arthritis |
|
|
 |
|
|
