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MR Vol.11 No3 indexに戻る
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MODERN RHEUMATOLOGY
Vol.11 No.3 |
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Psychiatric dysfunction in connective tissue
diseases: association with Sjogren's syndrome |
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| A Mitsuo1, S. Aotsuka1, H. Iwata2, M. Kinoshita2,
M. Sumiya2 |
(1)Division of Clinical Immunology, Clinical
Research Institute, International Medical Center of Japan, 1-21-1
Toyama, Shinjuku-ku, Tokyo 162-8655, Japan
(2)Division of Rheumatology, International Medical Center of Japan, Tokyo,
Japan |
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| Abstract |
| Abstract We studied 217 patients with connective
tissue disease (CTD), comprising 55 patients with primary Sjogren's
syndrome (SS), 34 with secondary SS, and 128 without SS. Psychiatric
manifestations were investigated using three questionnaires: the
Arthritis Impact Measurement Scale 2 (AIMS2), the Cornell Medical
Index (CMI), and the Beck Depression Inventory (BDI). Stratified
analysis revealed that the frequency of a neurotic state (levels
III + IV in CMI) in both primary SS patients (53%; 29% + 24%) and
secondary SS patients (67%; 41% + 26%) was significantly greater
than in CTD patients without SS (34%; 20% + 14%) (P < 0.05 and
P < 0.001, respectively). The median and Q1-Q3 BDI scores in secondary
SS patients (7.5 and 4.0-20.0) were significantly higher than those
in CTD patients without SS (5.0 and 1.0-10.0) (P < 0.05). Neither
the frequency of a neurotic state nor the BDI score differed significantly
between patients with primary SS and those with secondary SS. Regression
analysis showed significant correlations between the AIMS2 level-of-tension
scale and CMI classifications (rs = 0.676, P < 0.001), and between
the AIMS2 mood scale and BDI score (rs = 0.679, P < 0.001). SS
should always be borne in mind when patients with sicca syndrome
and multifarious psychiatric complaints are examined. |
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| Key words |
| Key words Arthritis Impact Measurement Scale
2 ・ Beck Depression Inventory ・ Cornell Medical Index ・ Sjogren's
syndrome |
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