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MR Vol.11 No3 indexに戻る
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MODERN RHEUMATOLOGY
Vol.11 No.3 |
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The osteoclast: a potential therapeutic target
of bone and joint destruction in rheumatoid arthritis |
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| S. Tanaka A1, K. Nakamura A1, H. Oda A1 |
| (1)Department of Orthopaedic Surgery, Faculty
of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo
113-0033, Japan |
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| Abstract |
| Abstract There is accumulating evidence that
osteoclasts, the primary cells responsible for bone resorption,
are involved in bone and joint destruction in rheumatoid arthritis
(RA). Recent progress in bone cell biology has revealed the molecular
mechanism of osteoclast differentiation and bone resorption by
mature osteoclasts. We here highlight the potential role of RANKL-RANK
pathways in bone destruction in RA. We also describe our recent
trials on gene therapy of arthritic joint disease targeting osteoclasts
by regulating Src kinase activity in the cells. |
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| Key words |
| Key words Adenovirus ・ C-terminus Src family
kinase (Csk) ・ Osteoclast recepter activator of NF-&kgr;B
ligand (RANKL) ・ Src |
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