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MR Vol.11 No.2 indexに戻る
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MODERN RHEUMATOLOGY
Vol.11 No.2 |
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Comparative evaluation of KL-6 and surfactant
protein D as serum markers for interstitial pneumonia associated
with collagen diseases |
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| T. Yoshitama1, A. Yamaguchi1, T. Izumihara2,
T. Matsuda2, S. Nagai2, T. Niimura2, C. Tei1 |
(1)First Department of Internal Medicine,
Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka,
Kagoshima 890-8520, Japan
(2) Center for Rheumatic Disease, Kagoshima Red Cross Hospital, Kagoshima,
Japan |
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| Abstract |
| Abstract We evaluated the usefulness of serum
levels of KL-6 and surfactant protein D (SP-D) as markers of interstitial
pneumonia (IP) associated with collagen diseases in 115 patients.
KL-6 and SP-D levels in patients with IP (n = 38) were significantly
higher than those in patients without IP (n = 77). Moreover, KL-6
and SP-D levels in patients with active IP (n = 8) were significantly
higher than those in patients with inactive IP (n = 30). Both KL-6
and SP-D proved useful for the diagnosis of IP associated with collagen
diseases and for the evaluation of disease activity. We classified
IP into three groups according to the extent of the lesion on computed
tomographs of the chest. There was a significant difference among
three groups in serum levels of KL-6, but not in serum levels of
SP-D. KL-6 proved to be useful as an indicator of the extent of the
IP lesions. We monitored changes in KL-6 and SP-D levels in seven
of eight patients with active IP. Chronological changes of serum
KL-6 and SP-D in patients with active IP were different. In fatal
cases in particular, serum levels of SP-D decreased at the terminal
stage of IP while levels of KL-6 continued to increase. |
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| Key words |
| Key words Collagen diseases ・ Interstitial
pneumonia ・ KL-6 ・ Serum marker ・ SP-D |
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