 |
MR Vol.11 No.2 indexに戻る
 |
MODERN RHEUMATOLOGY
Vol.11 No.2 |
 |
|
|
 |
|
|
Hematopoietic stem cell transplantation for the
treatment of autoimmune diseases |
|
|
| A. Suwa1 |
| (1) Department of Internal Medicine, Keio
University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo
160-8582,
Japan |
| |
| Abstract |
| Abstract Systemic autoimmune diseases that are
resistant to conventional treatment cause considerable morbidity
and mortality. Although aggressive new approaches to treating autoimmune
diseases have been developed over the past decade, there are still
patients with a severe, progressive, and life-threatening course.
Based on animal studies and experience in the treatment of hematological
disorders with preexisting autoimmune disease, hematopoietic stem
cell transplantation has been proposed for the treatment of severe
autoimmune diseases. Immunoablation and subsequent autologous peripheral
blood stem cell transplantation using CD34+ hematopoietic cells with
T cell depletion have been used for selected severe autoimmune diseases
at many institutes in Australia, Europe, and the United States. However,
it is necessary to assess the efficacy and safety of this therapy
compared with conventional and other newly emerging therapies. |
| |
| Key words |
| Key words Autoimmune disease ・ Bone marrow ・
Hematopoietic stem cell transplantation ・ Therapy |
|
|
 |
|
|
