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MR Vol.11 No.1 indexに戻る
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MODERN RHEUMATOLOGY
Vol.11 No.1 |
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Predictors of rheumatoid arthritis in patients
who have monoarthritis in a knee joint |
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| N. Tanaka1, Y. Yamada2, H. Sakahashi1,
E. Sato1, S. Ishii2 |
(1)Rheumatology Unit, Gorinbashi Orthopedic
Hospital in Gorinbashi Health Care Facilities and Hospitals, 2-1
Kawazoe, Minami-ku, Sapporo 005-0802, Japan
(2) Department of Orthopedic Surgery, School of Medicine, Sapporo Medical University,
Sapporo, Japan |
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| Abstract |
| Abstract To determine the predictive factors
for rheumatoid arthritis (RA), 79 patients (11 men, 68 women; average
age at onset of symptoms 37.1 years) with fixed joint effusion
of one knee joint, of minimum 6 months' duration, were divided
into three groups: group I, 11 patients (14%) who progressed to
RA; group II, 8 patients (10%) with the correct diagnosis, except
that RA became apparent during the subsequent follow-up; group
III, 60 patients (76%) whose joint effusion resolved. In group
I, the degree of joint effusion and the serological values of interleukin
(IL)-1#, IgG-RF, and rheumatoid factor (RF) tended to be higher
than those in the other groups at the time of our initial examination.
The synovial fluid concentrations of IL-1# and IgG-RF in group
I were significantly higher than those in the other groups. Magnetic
resonance imaging (MRI)-determined stage and histological assessment
of synovial inflammation also tended to be higher in group I than
in the other groups. This study revealed that it might be possible
to predict the outcome of cases of monoarthritis by examining IL-1#
and IgG-RF levels in the synovial fluid, in addition to various
elevated inflammation signs in the knee joint. |
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| Key words |
| Key words Interleukin-1 ・ Rheumatoid factor
・ Rheumatoid monoarthritis ・ Synovial fluid |
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